Applies only to oral form of both agents. Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. Applies only to oral form of both agents. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. Venofer Injection Prescribing Information - Drugs.com There is no resource limitation, as if the tool was hosted on your site, so all your users can make use of it 24/7; The necessary tool updates will take place in real time with no effort on your end; A single click install to embed it into your pages, whenever you need to use it. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. Applies only to oral form of both agents. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. Pain, swelling, or redness at the injection site may occur. Modify Therapy/Monitor Closely. Separate dosing of tetracyclines from these products. Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. Feraheme does not contain antimicrobial preservatives. Iron Sucrose Protocol - Cmqcc Iron Injection Administration | INJECTAFER HCP 1) Ganzoni AM. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. Kidney Int. 4. Fatal reactions have followed the test dose of iron dextran injection. Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. MISSED DOSE: It is important to get each dose of this medication as scheduled. Ganzoni Equation for Iron Deficiency Anemia - MDCalc Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. We'll do this entirely for free, as long as the calculator has applications for women's health. Applies only to oral form of both agents. Separate by 2 hr. Avoid or Use Alternate Drug. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. 1970;100(7):301303. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. 1970; 100(7):301-3. Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Iron Sucrose - Injection - Alberta 4. 2.1 . Applies only to oral form of both agents. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. Included in the iron dextran package insert. Do Not Copy, Distribute or otherwise Disseminate without express permission. By using this form you agree with the storage and handling of your data by this website. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. Venofer (iron sucrose) dose calculator | Calculosaurus.com Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Separate by at least 4 hours. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients. Burns DL, Mascioli EA, Bistrian BR. Official Journal of the International Society of Nephrology. Applies only to oral form of both agents. Applies only to oral form of both agents. Use Caution/Monitor. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Written by ASHP. Use Caution/Monitor. Volume of iron product required = 25 mL. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. Controlled studies in pregnant women show no evidence of fetal risk. The primary endpoint was the proportion of patients with . Use Caution/Monitor. iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Venofer has not been studied in patients younger than 2 years old. Applies only to oral form of both agents. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. Use Caution/Monitor. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] May increase risk of hypotension. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Modify Therapy/Monitor Closely. Otherwise, call a poison control center right away. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Objective. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] -Volume of parenteral iron product req'd (mL) = [Iron deficit (mg)] / C(mg/mL) Final calculations: -Hgb iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) -Volume of product required (mL) = [weight (kg)x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. Applies only to oral form of both agents. Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. Iron Deficiency in Heart Failure - Home - American College of Cardiology Injection site discoloration has been reported following extravasation. Applies only to oral form of both agents. Where: Medicine concentration Amount of active substance per a given volume of your drug. Venofer (Iron Sucrose Injection): Uses, Dosage, Side Effects - RxList Consult your doctor before breast-feeding. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. If these effects continue or worsen, tell your doctor.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. World J Gastroenterol; 16(22): 27202725. For liquid medications, also enter the value of the Medicine Concentration and choose . Parenteral iron dose - UpToDate Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. This document does not contain all possible drug interactions. Applies only to oral form of both agents. Use Caution/Monitor. Minor/Significance Unknown. ONE DOSE. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. Applies only to oral form of both agents. The iron formulation choice remains for the clinician to make. Use Caution/Monitor. Kumpf VJ. Venofer (iron sucrose) dose, indications, adverse effects - PDR View the formulary and any restrictions for each plan. Schweiz Med Wochenschr; 100(7):301-3. Your list will be saved and can be edited at any time. Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. elemental iron (mg/ml) in the product being used: Where C= DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia Anemia. 5. This site contains information for licensed healthcare professionals in the United States. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Either increases effects of the other by pharmacodynamic synergism. This drug is available at a higher level co-pay. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. The dosage of Venofer is expressed in mg of elemental iron. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) 2. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. 1. Monitor for signs and symptoms of hypotension following each Feraheme infusion. Use Caution/Monitor. Applies only to oral form of both agents. Minor (1)iron sucrose, captopril. Applies only to oral form of both agents. IDA diagnosis is based on full blood examination and on the serum ferritin level. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDDCKD has not - been established. Iron Sucrose - SlideShare Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. Koch TA, Myers J, Goodnough LT. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Mean change in Hgb from baseline to Week 5 2,5 Modify Therapy/Monitor Closely. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Intravenous iron sucrose for children with iron deficiency anemia: a Minor/Significance Unknown. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. Maximum infusion rate: 100 mg / hour (Slow infusion rate of iron sucrose is recommended to minimize adverse reactions, especially hypotension) Frequency of infusion: Dose may be repeated up to 3 times weekly to provide total iron dose. Dosage form: injection, solution Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. Dosing and Infusion Rates - PRIVIGEN (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Applies only to oral form of both agents. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . Initial infusion rate. May increase risk of hypotension. Use Caution/Monitor. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. Use Caution/Monitor. 1998 Feb;25(1):65-8. One dose IV Iron replacement | Monoferric nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Avoid or Use Alternate Drug. Venofer is given as an infusion into a vein. Always ask your health care professional for complete information about this product and your specific health needs. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. Use Caution/Monitor. There is in depth information below the form on the method used and on the result provided.
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